Radiation Carcinogenesis Epidemiology and Biological Significance (Progress in Cancer Research and Therapy ; V. 26) by John D., Jr. Boice

Cover of: Radiation Carcinogenesis | John D., Jr. Boice

Published by Raven Press .

Written in English

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  • Medicine,
  • Oncology,
  • Cancer,
  • Medical / Nursing,
  • Occurrence,
  • Radiation carcinogenesis,
  • Congresses,
  • Adverse effects,
  • Neoplasms, radiation-induced,
  • Radioactive fallout

Book details

The Physical Object
Number of Pages489
ID Numbers
Open LibraryOL8214902M
ISBN 100890049076
ISBN 109780890049075

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Radiation Carcinogenesis and DNA Alterations (Nato Science Series A: ()) th Edition by Frederic J. Burns (Editor) ISBN The meeting received finan­ cial support from the United States Department of Energy and the United States National Cancer Institute.

A plethora of recent developments in the molecular biology of DNA are leading to new ideas concerning how DNA alterations might be involved in the mechanism of radiation carcinogenesis. This book provides the first comprehensive and systematic survey of present knowledge about radiation carcinogenesis.

The mechanisms of skin cancer induction due to ultraviolet radiation, as well Radiation Carcinogenesis book arsenic induced tumors are examined. The concluding chapters describe some forms of skin tumors, such as adnexal tumors and basal cell epithelioma. This book will prove useful to oncologists and researchers in the field of Edition: 1.

Radiation carcinogenesis is a biological phenomenon whereby living normal cells are damaged by ionizing radiations, which starts a progressive process causing Radiation Carcinogenesis book surviving cells to change their phenotype such that normal controls of cell death and apoptosis are lost and uncontrolled cancerous growth is initiated.

New Aspects in Molecular and Cellular Mechanisms of Human Carcinogenesis. Edited by Written by an international team of experts in the field of human carcinogenesis, this book discusses recent advances in cancer research, which include the following topics: basic molecular and cellular mechanisms behind cancer growth, new approaches in cancer therapy, and cancer diagnostic.

Description. This newly revised and updated edition of Radiation Biophysics provides an in-depth description of the physics and chemistry of radiation and its effects on biological systems. Coverage begins with fundamental concepts of the physics of radiation and radioactivity, then progresses through the chemistry and biology of the interaction of radiation with living systems.

Whilst this information is available in various books and other reports, it is summarized and collated here so that the whole document has a degree of completeness. This should be helpful in particular to those countries that do not have easy Radiation carcinogenesis.

Mechanisms of carcinogenesis. 2. .) and. Radiation Carcinogenesis and Mutagenesis Experiments on bacteria, plants, fungi, tissues, and animal cultures Epidemiological method of the evaluation of the radiation action on humans The early history of radiation damage Radium stage Radiation experiments on people in the United States Radiation events after.

Cancer statistics and epidemiology, including a historical review of leukemia risk in A-bomb survivors, the incidence of solid cancer and resulting mortality, and the results of studies of workers exposed to low-level radiation.

Genetics, including the path from radiation exposure to cellular effects, carcinogenesis, and mutagenesis. Radiation-induced Breast Cancer happens to be prominent in the literature on radiation carcinogenesis (see GofmanBEIRfor instance).

Indeed, it provides a large share of the evidence of radiation carcinogenesis at the lowest possible dose and dose-rate per exposure (Gofman ). This volume is based on the proceedings of an Advanced Study Institute (ASI) sponsored by the North Atlantic Treaty Organization (NATO) held October in Corfu, Greece.

The meeting received finan­ cial support from the United States Department of Energy and the United States National Cancer Institute. A plethora of recent developments in the molecular biology of DNA are leading to.

As background to the studies of chemical and radiation carcinogenesis, the book surveys knowledge of cell transformation and carcinogen metabolism. Among the topics reviewed are the transforming genes involved in human malignancy, the genetics and epigenetics of neoplasia, and the single-hit and multi-hit concepts of hepatocarcinogenesis.

Furthermore, the underlying biological mechanisms implicated in radiation-associated carcinogenesis may also affect development of other degenerative diseases providing opportunities to identify shared pathways for cross-functional outcome monitoring and mitigation.

Characterization of the role radiation quality plays in space radiation. Risk of Radiation Carcinogenesis 5 I. PRD Risk Title: Risk of Radiation Carcinogenesis Description: In space, astronauts are exposed to ionizing radiation that is quantitatively and qualitatively different from terrestrial radiation.

This environment includes protons and high-Z. @article{osti_, title = {Radiation carcinogenesis: Epidemiology and biological significance}, author = {Boice, J.D. and Fraumeni, J.F.}, abstractNote = {Epidemiologic studies of populations exposed to radiation have led to the identification of a preventable cause of cancer, but in the long run perhaps the most important contribution of radiation studies will be to provide insights into the.

Ionizing radiation has been called a “universal carcinogen” in that it will induce cancer in most tissues of most species at all ages, including the fetus. It is one of the few definitely established carcinogens in human beings, and perhaps the only one for which firm dose-response data in human populations are available.

It is, however, a relatively weak carcinogen and mutagen when. Radiation carcinogenesis (2 titles, plus subtopics) Radiation carcinogenesis -- Prevention (1 title) Radiation counters: see Nuclear counters; Radiation disease: see Radiation injuries; Radiation -- Dosage (subtopics) Radiation -- Dosage -- Measurement: see Radiation dosimetry; Radiation dosimetry (1 title, plus subtopics) Radiation ecology.

Radiation Carcinogenesis: • Ultraviolet (UV) light and ionising radiation - two main forms of radiation carcinogens which can induce cancer in experimental animals and are implicated in causation of some forms of human cancers.

• A property common-the appearance of mutations followed by a long period of latency after initial exposure, often. A major goal of this book is to present and analyze the evidence concerning effects of low doses of radiation upon humans, and to demonstrate that a systematic and consistent evaluations of the evidence is now possible, with very useful practical results.

K.Z. Morgan, the subject and principal author of this biography, was a respected radiation protection scientist (health physicist), who died at shortly after this book was published.

If his silent co-author had been a health physicist, instead of “one of the best trial lawyers in America,” as the book jacket proclaims, the book. This volume explores molecular information specific to chemical, viral, and radiation carcinogenesis, explains the working of cellular oncogenes and tumor suppressor genes, and also introduces readers to the latest genomic and proteomic s: 2.

Stephen Mastorides, R.R. Maronpot, in Handbook of Toxicologic Pathology (Second Edition), 2. Rat Mammary Neoplasm Test. The rat mammary neoplasm test is based on a carcinogenesis model first reported by Huggins and co-workers in Single or sometimes multiple doses of agent are given to virgin female Sprague–Dawley rats at around day 55 of age, which corresponds to maximum.

NCI's Dictionary of Cancer Terms provides easy-to-understand definitions for words and phrases related to cancer and medicine. “Radiation is a carcinogen.” This has been known since the time of Marie Curie and confirmed by the experience of the Japanese from the atomic bombs at Hiroshima and Nagasaki.

Marie Curie developed leukemia after doing research on radioactivity. Radiation causes DNA mutations in radiated cells which can be transmitted to later generations.

(A related field is the use of known cross-linking reactions to gain information on structural associations in macromolecular complexes.); (3) the relevance of DNA adducts to chemical and radiation carcinogenesis; (4) the rele­ vance of DNA adducts to the cross-linking theory of cellular : $ The major mechanisms of radiation carcinogenesis are linked to DNA damage associated with it misrepaired DNA lesions and the induction of mutations, our knowledge of which is summarized in excellent reviews elsewhere.

1,15 In addition to these mechanisms, the development of radiation-induced genomic instability, a multifactorial phenomenon. According to a new approach to cancer risk assessment, based on an apoptotic model of carcinogenesis, it was determined that proximity to EMR from cellphone towers may pose a potential cancer risk in humans since microwave radiation can induce various apoptotic pathways leading to cell death in transformed human cell lines.

Share this book. Facebook. Twitter. Pinterest. Embed. Edit. Last edited by Clean Up Bot. Febru | History. An edition of Radiation and human health () Radiation and human health by John W.

Gofman. 0 Ratings. Contents may have variations from the printed book or be incomplete or contain other coding. Mettler TOC Contents 1 Basic Radiation Physics, Chemistry, and Biology 2 Sources of Radiation Exposure 3 Effects on Genetic Material 4.

Cancer Induction and Dose-Response Models 5 Carcinogenesis of Specific Organ Sites 6 Deterministic Effects of. This handbook presents the most current information on the effects of ionizing radiation on mammalian cells, with emphasis on human tissues.

The dose-effect relationship is emphasized in a quantitative manner. The book contains up-to-date data on the late effects of low levels of radiation on humans. It also provides some of the late consequences of radiation therapy detected among cancer.

Exposure to ionizing radiation is known to increase the future incidence of cancer, particularly mechanism by which this occurs is well understood, but quantitative models predicting the level of risk remain controversial. The most widely accepted model posits that the incidence of cancers due to ionizing radiation increases linearly with effective radiation dose at a rate of %.

Excerpt from Carcinogenesis Abstracts, Vol. 3: January ; Abstracts Nos. Carcinogenesis Abstracts will be published monthly and will include abstracts from journals received primarily the month previously.

About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. There is strong evidence that a critical step in carcinogenesis is a structural alteration occurring in the genetic machinery of a somatic cell.

This appears to be true whether the active agent is a chemical or ionizing radiation, or if the. Carcinogenesis covers molecular, biochemical and cellular processes that underpin this field.

CARCINOGENESIS BY IONIZING RADIATION TABLEIII RATIO OF SPONTANEOUS CANCER MORTALITY RATES TO LEUKEMIA MORTALITY RATES (Derived from U.S. Vital Statistics for ) Males Agegroup Rati (Spontaneous cancermortality ratesA (years) RA F_ Leukemiamortality rates (40 44 In these studies 40 per.

Radiation Carcinogenesis 2. Two types of late effects of irradiation • Deterministic (non-stochastic) effects – Severity increases with dose. There is a threshold. Eg tissue fibrosis, cataracts. – Mechanism involves effects (often cell kill) on many cells.

• Stochastic Effects – No threshold, probability increases with dose but. However, if radiation carcinogenesis proceeds through the hosts’ recovery processes from damage in normal tissues, there could be a possibility in the future that it might be possible to develop methods to mitigate radiation-induced carcinogenesis processes.

33 Specific approaches toward this goal may include, for example, controls on the. The book also includes extensive discussion of the practical impact of radiation on everyday life. Stochastic Effects--Radiation Carcinogenesis Stochastic Effects, Genetic Effects of Ionizing Radiation High LET Radiation Effects Metabolism and Biological Effects of Deposited RadionuclidesPrice: $ Table 8–1 lists definitions of terms commonly used in discussing chemical carcinogenesis.

For benign neoplasms, the tissue of origin is frequently followed by the suffix “oma”; e.g., a benign fibrous neoplasm would be termed fibroma, and a benign glandular epithelium termed an ant neoplasms from epithelial origin are called carcinomas, whereas those derived from mesenchymal.

With regard to skin cancer, the aberrant expression of lncRNA appears to be functionally important in skin carcinogenesis.

In one study, lncRNA lincRNA-p21—a transcriptional target of p53 and HIF-1α—was found to be highly inducible by UVB radiation and crucial for p mediated apoptosis of damaged keratinocytes. Mathematical Models of Radiation Carcinogenesis." National Research Council. Health Effects of Exposure to Low Levels of Ionizing Radiations: Time for Reassessment?.

Washington, DC: The National Academies Press. doi: / ×.Advances in Radiation Biology: Volume 4, Volume 4 - Ebook written by John T. Lett, Howard Adler, Max Zelle. Read this book using Google Play Books app on your PC, android, iOS devices.

Download for offline reading, highlight, bookmark or take notes while you read Advances in Radiation .The early human experience with carcinogenesis but largely anecdotal (not based on fact/research): 1- Skin cancer and leukemia in the x-ray workers who worked around accelerators(before introduction of radiation safety protocols) 2- Lung cancer-- intense local a-radiation 3- Bone tumors-- radium dial painters injection of radium salts for tx of tuberculosis or ankylosing spondylitis.

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